Another way to say
anguish, distress, anxiety, wretchedness, worry, danger, pain, peril, grief, disaster, misfortune, concern, difficulty, inconvenience, effort, exertion
To disturb mental calm; to cause bodily discomfort or pain; to vex, bother, or annoy; to agitate, dsturb, or stir up
"I could tell by the way she was crying that she was in distress."
"I'm having trouble with my knees."
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