The phrase 'take with a grain of salt' means that the listener should to take the source of the information as prone to be unreliable or exaggerated.
Example of use: "Yolanda tells some great stories, but we take what she says with a grain of salt because she has quite a vivid imagination and tends to exaggerate."
"Take it with a grain of salt" is more common in American and Australian English, while "take it with a pinch of salt" is more common in British English.